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The manner which measures the bone damage present easiness due to the screening doing pleomorphism of the vitamin D receptor gene
The manner which measures the bone damage present easiness due to the screening doing pleomorphism of the vitamin D receptor gene
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机译:由于对维生素D受体基因进行了多态性的筛查,因此测量骨损伤的易感性的方法
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摘要
The present invention relates to a prognostic method and means for determining susceptibility to bone damage in a subject, by screening for polymorphisms in the Vitamin D receptor or collagen Ialpha1 genes. In particular, the method for determining susceptibility to bone damage comprises analyzing the genetic material of a subject to determine which of the B/b, A/a or T/t alleles of the restriction enzyme sites BsmI, ApaI and TaqI respectively are present. The method may further comprise determining which allele is present at die SpI restriction site of the collagen Ialpha1 gene. Specific combinations of the above alleles represent a haplotype which is associated with susceptibility to bone damage.
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