The maturity type protein which shows the antagonist activity for the bone formation protein

摘要

(57) Abstract Purpose is offer of the maturity type protein which possesses the antagonist activity for the bone formation protein. The maturity type protein which possesses the antagonist activity for the bone formation protein inside the methionine residue or the toriputohuan residue which is in the midst of amino acid arranging of maturity type person MP52 of arrangement number 1 at least 1 amino acid residues, converts to the hydrophilic amino acid residue with chemical decoration, or, substituting in hydrophilic amino acid, or polarity amino acid can. Chemical decoration of the methionine residue is done by the oxidation reaction or the alkylation reaction. Chemical decoration of the toriputohuan residue is done by the allyl sail phenyl conversion reaction. In addition, the maturity type protein where at least 1 amino acid residues of the toriputohuan residue which is in the midst of amino acid arranging of maturity type person BMP-7 of maturity type person BMP-2 of arrangement number 2, maturity type person BMP-4 of arrangement number 3, and arrangement number 4, with chemical decoration in hydrophilic amino acid, or polarity amino acid to the hydrophilic amino acid residue it converts, substituting can, the antagonist activity for the bone formation protein shows.