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How polyfunctional cationic cytofectins, and formulations for the production of polynucleotide transfection complexes: active cytofectins
How polyfunctional cationic cytofectins, and formulations for the production of polynucleotide transfection complexes: active cytofectins
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机译:多功能阳离子细胞转染素以及用于生产多核苷酸转染复合物的制剂:活性细胞转染素
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摘要
Amine containing compounds and their use in the generation of cytofectin:polynucleotide complexes for transfection of cells, formulations, counterions, and reaction conditions for maximizing the transfection include using cationic amine compounds that have general structure (I), wherein R4 and R5 are a pair of same or different lipoyl moieties selected from a group consisting of an alkyl, alkenyl, alkynyl, alkanoyl, alkenoyl, or alkynoyl groups and for R1, R2, and R3 at least two are hydroxylated, ether containing, or acyloxy containing alkyl, alkynyl, or alkynyl groups or at least one amine bonded halogen containing moiety selected from a group consisting of a halogenated alkyl, alkenyl, or alkynyl group or a mixture of at least one halogen containing moiety selected from a group consisting of a halogenated alkyl, alkenyl, or alkynyl group and at least one hydroxylated, ether containing, or acyloxy containing alkyl, alkenyl, or alkynyl group, and X- is an oxyanion or halide counterion.
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