首页>
外国专利>
Polyamides that bind to predetermined DNA sequences at sub-nanomolar concentrations
Polyamides that bind to predetermined DNA sequences at sub-nanomolar concentrations
展开▼
机译:在亚纳摩尔浓度下结合预定DNA序列的聚酰胺
展开▼
页面导航
摘要
著录项
相似文献
摘要
Novel small molecule polyamides of Formula (I) that specifically bind with subnanomolar affinity to any predetermined sequence in the human genome with potential use in molecular biology and human medicine are described. Further, the designed compounds which target the minor groove of B-form double helical DNA offer a general approach for the control of gene-expression. Simple rules are disclosed which provide for rational control of the DNA-binding sequence specificity of synthetic polyamides containing N-methylpyrrole and N-methylimidazole amino acids. A series of molecular templates for polyamide design are disclosed which provide for small molecules which recognize predetermined DNA sequences with affinities and specificities comparable to sequence specific DNA-binding proteins such as transcription factors.
展开▼