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Method of screening for a compound capable of inhibiting the binding between the transcription factor USF1 transcription factors STAT1
Method of screening for a compound capable of inhibiting the binding between the transcription factor USF1 transcription factors STAT1
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机译:筛选能够抑制转录因子USF1转录因子STAT1之间结合的化合物的方法
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摘要
The invention concerns a method for determining whether a candidate compound is capable of inhibiting fixing between STAT1 and USF1 polypeptides comprising the following steps: (a) provide all or part of the STAT1 polypeptide capable of fixing with the USF1 polypeptide; (b) providing all or part of the USF1 polypeptide capable of fixing with the STAT1 polypeptide; (c) contacting said polypeptides as defined in (a) and (b) with one said candidate compound in conditions suitable for fixing between STAT1 and USF1 polypeptides; (d) measuring the fixing between the STAT1 and USF1 polypeptides; and (e) comparing said measurement with the fixing measurement between STAT1 and USF1 polypeptides in similar experimental conditions in the absence of said candidate compound, a decrease in fixing leading to conclude that said compound candidate is capable of inhibiting fixing between STAT1 and USF1 polypeptides.
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