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Method for screening compounds capable of inhibiting binding between the transcription factor of STAT1 and the transcription factor of USF1
Method for screening compounds capable of inhibiting binding between the transcription factor of STAT1 and the transcription factor of USF1
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机译:筛选能够抑制STAT1转录因子与USF1转录因子结合的化合物的方法
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摘要
The invention concerns a method for determining whether a candidate compound is capable of inhibiting fixing between STAT1 and USF1 polypeptides comprising the following steps: (a) provide all or part of the STAT1 polypeptide capable of fixing with the USF1 polypeptide; (b) providing all or part of the USF1 polypeptide capable of fixing with the STAT1 polypeptide; (c) contacting said polypeptides as defined in (a) and (b) with one said candidate compound in conditions suitable for fixing between STAT1 and USF1 polypeptides; (d) measuring the fixing between the STAT1 and USF1 polypeptides; and (e) comparing said measurement with the fixing measurement between STAT1 and USF1 polypeptides in similar experimental conditions in the absence of said candidate compound, a decrease in fixing leading to conclude that said compound candidate is capable of inhibiting fixing between STAT1 and USF1 polypeptides.
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