Method of manufacturing the new wilderness e indole

摘要

The areno(e)indols have the formula (I). The methods comprises: (a) reacting (VI) with a strong base and thereafter with an aldehyde Ar'-CHO to obtain (VII); (b) oxidizing (VII) to yield the cetone (VIII); (c) reating (VIII) with a strong base and thereafter with an acyle chloride ClCOR, to produce (IX); (d) subjecting to a photochemical cyclization (IX) to produce (I). In said formulas Ar is phenyl or substituted phenyl; Ar' is a radical (i) or (ii); R is an acyle group, Ar' is a phenyl, pyrolyl, furanyl or thiophenyl group substituted up to three times by any of the radicals R, R?1, R2, or R3¿. The compounds (I) are useful as intermediates in the synthesis of hexahydroareno(e)cyclopropa(c)indol-4-ones with antitumoral activity.