FUSED IMIDAZOLE DERIVATIVE AS AGENT HAVING MULTIDRUG RESISTANCE MODULATING PROPERTIES

摘要

PROBLEM TO BE SOLVED: To provide a fused imidazole derivative having multidrug resistance modulating properties capable of inhibiting or reversing multiple drug resistance of a carcinoma cell or a pathogen. SOLUTION: This compound is expressed by formula (I). [In the formula a dotted line is a bond existing according to circumstances; n is 1 or 2; R1 is H, a halo, formyl group, a l-4C (substituted)alkyl group, -X-CO-OR5,-X-CO-NR6 R7 or -X-CO-R10; R2 is H, a halo, a 1-4C alkyl group, a 1-4C hydroxyalkyl group, a 1-4C alkyloxycarbonyl group, a carboxyl group, formyl group or a phenyl group; R3 is H, a 1-4C alkyl group, or a 1-4C alkyloxy group; R4 is H, a halo, a 1-4C alkyl group, or a 1-4C alkyloxy group or a 1-4C haloalkyl group; Z is -CH2-, -CH2-CH2-, -CH=CH-, -CHOH-CH2-, -O-CH2, -C(=O)-CH2- or -C(= NOH)-CH2-; -A-B- is a divalent group; -A1- is a direct bond, a 1-6C substituted alkanediyl, a 1-6C alkanediyl-oxy-1-6C alkanediyl, a carbonyl, a 1-6C alkanediylcarbonyl, 1-6C (substituted) alkanediyloxy; A2 is a direct bond or a 1-6C alkanediyl; Q is an aryl group].