(Asu1.7) stabilization method null of aqueous solution injection medicine of karushitonin

摘要

PURPOSE:To provide the subject aqueous solution injection containing a specified pH buffer and stabilized in a wider pH range than in the conventional one. CONSTITUTION:In an aqueous solution injection containing an [Asu1.7] calcitonin, e.g. elcatonin or [Asu1.7] human calcitonin as the active component, one or two or more kinds of compounds selected from a group of tris(hydroxymethyl) aminomethane, an amine compound of the formula (R1 to R3 are each H or CH2-CH2-OH, at least one of them is CH2-CH2-OH) and water-soluble salts thereof are contained as the pH buffers so as to stabilize the pH within a range of 6.5 to 8. This aqueous solution injection contains 0.01 to 100mug/ml calcitonin and 0.05 to 100 mM pH buffers.