6,5-UNITED AROMATIC RING SYSTEM HAVING POTENTIATED PHOSPHODIESTERASE IV INHIBITING ACTIVITY

摘要

PROBLEM TO BE SOLVED: To obtain a new compound as an antiasthmatic agent which is a cyclic nucleotide phosphodiesterase(PDE) IV inhibitor.;SOLUTION: This compound comprises a compound represented by formula (I) (wherein, ring A and ring B may contain an unsaturated bond; X1 denotes CH, C-Cl or N; X2 denotes a CR or N; X3 denotes CH or N; X4 denotes CH or N; and M denotes C or N). 5-Chloro-2--(3,5-di-t-butyl-4-hydroxybenzyl)-7-[2-(2- pyridyl)-ethynyl]-benzoxazole is cited as an example.;COPYRIGHT: (C)2001,JPO