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Method for isolating cells expressing FLk-2 receptors and isolated populations of cells that express FLk-2 receptors
Method for isolating cells expressing FLk-2 receptors and isolated populations of cells that express FLk-2 receptors
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机译:分离表达FLk-2受体的细胞和分离表达FLk-2受体的细胞群的方法
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摘要
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1a (murine flk-2), FIG.1b (human flk-2) and FIG. 2 (murine flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1a, FIG. 1b and FIG. 2; ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
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机译:提供了分离的哺乳动物核酸分子,其编码在原始造血细胞中表达而在成熟的造血细胞中不表达的受体蛋白酪氨酸激酶。还包括由这种核酸分子编码的受体。编码具有图3所示序列的受体蛋白酪氨酸激酶的核酸分子。 1 B> a I>(鼠flk-2),图1 b I>(人flk-2)和图2分别为。 2 B>(鼠科动物flk-1);具有图1所示的氨基酸序列的受体蛋白酪氨酸激酶被合成。 1 B> a I>,图。 1 B> b I>和图。 2; B>受体的配体;编码配体的核酸序列;刺激原始哺乳动物造血干细胞的增殖和/或分化的方法和方法,包括使干细胞与与在原始哺乳动物造血细胞中表达但在成熟造血细胞中不表达的受体蛋白酪氨酸激酶结合的配体接触。
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