;wherein X1, X2 and X3 are individually selected from the group consisting of hydrogen, halogen, unsubstituted or substituted alkyl of 1 to 18 carbon atoms, unsubstituted or substituted alkenyl and alkynyl of 2 to 18 carbon atoms, unsubstituted or substituted alkoxy of 1 to 7 carbon atoms, OH, CF3, NO21 NH21 mono and dialkylamino of 1 to 4 alkyl carbon atoms and unsubstituted or substituted phenyl, chemistry chemdraw filechemistry mol file;R is selected from the group consisting of unsubstituted or substituted alkyl of 1 to 7 carbon atoms, unsubstituted or substituted alkenyl and alkynyl of 2 to 7 carbon atoms, unsubstituted or substituted phenyl and carboxy optionally salified or esterified, R1 is chemistry chemdraw filechemistry mol file;or CCHR10, one of R8 and R9 is selected from the group consisting of hydrogen, unsubstituted or substituted alkyl of 1 to 6 carbon atoms, unsubstituted or substituted alkenyl and alkynyl of 2 to 6 carbon atoms, unsubstituted or substituted phenyl, esterified carboxy, CN and acyl of 2 to 6 carbon atoms and the other and R10 are selected from the group consisting of hydrogen, unsubstituted or substituted alkyl of 1 to 6 carbon atoms, unsubstituted or substituted alkenyl and alkynyl of 2 to 6 carbon atoms and unsubstituted or substituted phenyl and its non-toxic, pharmaceutically acceptable salts with acids or bases having anti-anoxic, anti-ischemic and neuronal protective anti-depressant activities."/>
NOVEL 20,21-DINOR-EBURNAMENINE
A compound selected from the group consisting of all possible isomers or racemates of a compound of the formula chemistry chemdraw filechemistry mol file;wherein X1, X2 and X3 are individually selected from the group consisting of hydrogen, halogen, unsubstituted or substituted alkyl of 1 to 18 carbon atoms, unsubstituted or substituted alkenyl and alkynyl of 2 to 18 carbon atoms, unsubstituted or substituted alkoxy of 1 to 7 carbon atoms, OH, CF3, NO21 NH21 mono and dialkylamino of 1 to 4 alkyl carbon atoms and unsubstituted or substituted phenyl, chemistry chemdraw filechemistry mol file;R is selected from the group consisting of unsubstituted or substituted alkyl of 1 to 7 carbon atoms, unsubstituted or substituted alkenyl and alkynyl of 2 to 7 carbon atoms, unsubstituted or substituted phenyl and carboxy optionally salified or esterified, R1 is chemistry chemdraw filechemistry mol file;or CCHR10, one of R8 and R9 is selected from the group consisting of hydrogen, unsubstituted or substituted alkyl of 1 to 6 carbon atoms, unsubstituted or substituted alkenyl and alkynyl of 2 to 6 carbon atoms, unsubstituted or substituted phenyl, esterified carboxy, CN and acyl of 2 to 6 carbon atoms and the other and R10 are selected from the group consisting of hydrogen, unsubstituted or substituted alkyl of 1 to 6 carbon atoms, unsubstituted or substituted alkenyl and alkynyl of 2 to 6 carbon atoms and unsubstituted or substituted phenyl and its non-toxic, pharmaceutically acceptable salts with acids or bases having anti-anoxic, anti-ischemic and neuronal protective anti-depressant activities.
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