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Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus
Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus
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机译:确定2型糖尿病风险的预测方法中线粒体功能改变的指标
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摘要
The present invention relates to improved diagnostic methods for early detection of a risk for developing type 2 diabetes mellitus in humans, and screening assays for therapeutic agents useful in the treatment of type 2 diabetes mellitus, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.
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