首页>
外国专利>
Methods for treating seizure disorders by inhibiting MAPK pathway activation
Methods for treating seizure disorders by inhibiting MAPK pathway activation
展开▼
机译:通过抑制MAPK途径激活来治疗癫痫发作的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Excessive brain neuronal excitability, associated with a seizure disorder, can be correlated with increased mitogen-activated protein kinase (MAPK) activity in neurons. Such excessive excitability can be ameliorated by administering an effective amount of a compound, such as a MAPK phosphorylation or kinase activity inhibitor, that reduces the amount of MAPK activity in neurons of an individual suffering from a seizure disorder. Compounds that inhibit phosphorylation or kinase activity of upstream activators or downstream targets of the MAPK cascade also are useful in this context.
展开▼