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METHODS FOR TREATING SEIZURE DISORDERS BY INHIBITING MAPK PATHWAY ACTIVATION WITH NITRILES
METHODS FOR TREATING SEIZURE DISORDERS BY INHIBITING MAPK PATHWAY ACTIVATION WITH NITRILES
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机译:通过抑制腈的MAPK通路活化来治疗过敏性疾病的方法
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摘要
Excessive brain neuronal excitability, associated with a seizure disorder, can be correlated with increased mitogen-activated protein kinase (MAPK) activity in neurons. Such excessive excitability can be ameliorated by administering an effective amount of a compound, such as a MAPK phosphorylation or kinase activity inhibitor, that reduces the amount of MAPK activity in neurons of an individual suffering from a seizure disorder. Compounds that inhibit phosphorylation or kinase activity of upstream activators or downstream targets of the MARPK cascade also are useful in this context.
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