The invention provides methods of treating a subject at risk for a heart disorder. The method includes delivering a compound to the heart of a subject which alters the ratio of SERCA2a and phospholamban in the heart or heart cells of a subject. The invention also provides methods of evaluating a treatment for a heart disorder; a heart cell, into which has been introduced by somatic gene transfer, a nucleic acid which results in the expression of phospholamban; a heart tissue, into which has been introduced by somatic gene transfer, a nucleic acid which results in the expression of phospholamban; and a heart, into which has been introduced by somatic gene transfer, a nucleic acid which results in the expression of phospholamban.
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