Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta b 1,4 diazepino- 6,7,1-hi indole derivatives

摘要

This invention provides a process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopentab1,4diazepino6, 7, 1-hiindole derivatives of the general formula: chemistry chemdraw filechemistry mol file;wherein: ;R is H, alkyl, cycloalkyl, CH₂-cycloalkyl, acyl, aryl or aroyl; R₁, R₂, R₄ and R₅ are H, hydroxy, alkyl, cycloalkyl, alkoxy, halogen, fluorinated alkyl, CN, NHSO₂-alkyl, SO₂NH-alkyl, alkyl amide, amino, alkylamino, dialkylmino, fluorinated alkoxy, acyl, aryl or aroyl; R₃ is H, alkyl, cycloalkyl, alkoxy, fluorinated alkyl, alkyl sulfonamide, alkyl amide, amino, alkylamino, dialkylmino, fluorinated alkoxy, acyl, aryl or aroyl; ;or a pharmaceutically acceptable salt thereof, as well as intermediates for their synthesis.