This invention provides a process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino[6,7,1-hi]indole derivatives of the general formula: wherein: R is H, alkyl, cycloalkyl, —CH2-cycloalkyl, acyl, aryl or aroyl; R1, R2, R4 and R5 are H, hydroxy, alkyl, cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —SO2—NH-alkyl, alkyl amide, amino, alkylamino, dialkylmino, fluorinated alkoxy, acyl, aryl or aroyl; R3 is H, alkyl, cycloalkyl, alkoxy, fluorinated alkyl, alkyl sulfonamide, alkyl amide, amino, alkylamino, dialkylmino, fluorinated alkoxy, acyl, aryl or aroyl; or a pharmaceutically acceptable salt thereof, as well as intermediates for their synthesis.
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机译：本发明提供了制备1、2、3、4、8、9、10、10a-八氢-7bH-环戊[b] [1,4]二氮杂[6,7,1-hi]吲哚衍生物的方法通式： <图像alt =“嵌入式图像” file =“ US06916922-20050712-C00001.GIF” he =“ 36.49mm” imgContent =“ chem” imgFormat =“ GIF” wi =“ 50.88mm“ /> 其中：R为H，烷基，环烷基，-CH 2 -环烷基，酰基，芳基或芳酰基; R 1 ，R 2 ，R 4 和R 5 是H，羟基，烷基，环烷基，烷氧基，卤素，氟化烷基，-CN，-NH-SO 2 -烷基，-SO 2 -NH-烷基，烷基酰胺基，氨基，烷基氨基，二烷基氨基，氟化烷氧基，酰基，芳基或芳酰基; R 3 为H，烷基，环烷基，烷氧基，氟化烷基，烷基磺酰胺，烷基酰胺，氨基，烷基氨基，二烷基氨基，氟化烷氧基，酰基，芳基或芳酰基;或其药学上可接受的盐，以及用于其合成的中间体。
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