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Design and discovery of protein based TNF-alpha variants for the treatment of TNF-alpha related disorders

机译：设计和发现用于治疗TNF-alpha相关疾病的基于蛋白质的TNF-alpha变体

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摘要

The invention relates to novel proteins with TNF-&agr; antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-&agr; related disorders, such as rheumatoid arthritis.

机译：本发明涉及具有TNF-α的新型蛋白质。拮抗剂活性和编码这些蛋白质的核酸。本发明还涉及所述新型蛋白在治疗TNF-α中的用途。相关疾病，例如类风湿关节炎。

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公开/公告号US2002009780A1

专利类型
公开/公告日2002-01-24

原文格式PDF
申请/专利权人 DAHIYAT BASSIL I.;FILIKOV ANTON;
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申请/专利号US20010798789
发明设计人 ANTON FILIKOV;BASSIL I. DAHIYAT;
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申请日2001-03-02
分类号C12P21/02;C07H21/04;C12N5/06;A61K38/19;C07K14/52;
国家 US
入库时间 2022-08-22 00:49:31

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