首页>
外国专利>
Transgenic animal models for cardiac hypertrophy and methods of use thereof (screening)
Transgenic animal models for cardiac hypertrophy and methods of use thereof (screening)
展开▼
机译:心脏肥大的转基因动物模型及其使用方法(筛选)
展开▼
页面导航
摘要
著录项
相似文献
摘要
Transgene constructs for generating transgenic animals, wherein the transgene encodes a gene product which modulates transcription of a hypertrophy-sensitive gene, are provided. Further provided are recombinant vectors comprising the transgenes of the invention. Further provided are transgenic animals generated using the transgene constructs. Further provided are enzyme-based, cell-based, and whole-animal-based assays for detecting substances having therapeutic activity toward cardiac hypertrophy. Further provided are compositions comprising substances which modulate levels of active product of a hypertrophy-sensitive gene. Further provided are methods of treating cardiac hypertrophy.
展开▼