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Staphylococcus strains comprising an inducible gene encoding an RNA polymerase specificity factor
Staphylococcus strains comprising an inducible gene encoding an RNA polymerase specificity factor
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机译:包含编码RNA聚合酶特异性因子的可诱导基因的葡萄球菌菌株
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摘要
The present invention relates to a recombinant organism, and a bacterial strain such as Staphylococcus, and S. aureus, in particular. The organism has a regulatable gene for encoding an RNA polymerase specificity factor required for expression of at least one gene essential for growth of the organism. The regulatable gene is one which is responsive to an exogenous effector molecule, and may in particular be an inducer-responsive gene including an operator site, such as a lac operator, to which a repressor, such as a lacl-encoded repressor, is capable of binding. The regulatable gene may in particular be an IPTG responsive plaC allele.
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