首页>
外国专利>
Chicken monoclonal antibodies specific for coccidial antigens involved in invasion of host lymphocytes
Chicken monoclonal antibodies specific for coccidial antigens involved in invasion of host lymphocytes
展开▼
机译:鸡球蛋白特异性针对参与宿主淋巴细胞入侵的球蛋白抗原
展开▼
页面导航
摘要
著录项
相似文献
摘要
A stable chicken hybridoma secreting a monoclonal antibody (mAb) that detects the conoid structure of Eimeria acervulina (E. acervulina) sporozoites has been developed. The hybridoma is made by fusing a thymidine kinase (TK)-deficient chicken myeloma with spleen cells from chickens immunized with sporozoite antigen. The monoclonal antibody recognizes sporozoite proteins on the conoid of the anterior tip of E. acervulina sporozoites. The monoclonal antibody has been shown to inhibit the invasion of sporozoites into CD8+ T cells in vitro thereby indicating its role in the recognition of host cells during the invasion process following infection with Eimeria parasites.
展开▼