首页> 外国专利> Human metabotropic glutamate receptor subtype mGluR6 protein

Human metabotropic glutamate receptor subtype mGluR6 protein

机译:人类代谢型谷氨酸受体亚型mGluR6蛋白

摘要

In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtype mGluR6, and the proteins encoded thereby. In addition to being useful for the production of metabotropic glutamate receptor subtype mGluR6, nucleic acids of the invention are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits. In addition to disclosing a novel metabotropic glutamate receptor subtype, mGluR6, the present invention also comprises methods for using the invention receptor subtype to identify and characterize compounds which affect the function of such receptor subtype, e.g., agonists, antagonists, and modulators of glutamate receptor function.
机译:根据本发明,提供了编码人代谢型谷氨酸受体亚型mGluR6的核酸,以及由此编码的蛋白质。除了可用于产生促代谢型谷氨酸受体亚型mGluR6之外,本发明的核酸还可用作探针,从而使本领域技术人员无需过多实验即可鉴定和分离相关的人受体亚基。除了公开新型的代谢型谷氨酸受体亚型mGluR6之外,本发明还包括使用本发明的受体亚型来鉴定和表征影响此类受体亚型功能的化合物的方法,例如激动剂,拮抗剂和谷氨酸受体调节剂。功能。

著录项

  • 公开/公告号US6362316B1

    专利类型

  • 公开/公告日2002-03-26

    原文格式PDF

  • 申请/专利权人 MERCK & CO. INC.;

    申请/专利号US19990277858

  • 发明设计人 LORRIE P. DAGGETT;CHIN-CHUN LU;

    申请日1999-03-26

  • 分类号C07K147/05;C07K147/10;C12N51/00;C12N151/20;C12N156/30;

  • 国家 US

  • 入库时间 2022-08-22 00:48:24

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