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Catalysts for asymmetric addition of organozinc regents to aldehydes and method for preparation
Catalysts for asymmetric addition of organozinc regents to aldehydes and method for preparation
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机译:用于将有机锌试剂不对称加成到醛中的催化剂及其制备方法
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摘要
Chiral aminoalcohol catalysts and methods for their preparation are provided. The first catalyst is prepared via selective hydrogenation of one of two benzene rings in a precursor. The aminoalcohol promotes the asymmetric addition of organozinc reagents to aldehydes to afford optically active alcohols or their esters. The second catalyst is prepared by selective dialkylation of 3-exo-aminoisoborneol with a 2-haloethyl ether. The aminoalcohol promotes the addition of organozinc reagents to aliphatic aldehydes containing a &bgr;-branch with greatly enhanced enantioselectivity relative to DAIB.
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