Flow-through, hybrid magnetic field gradient, rotating wall device for enhanced colloidal magnetic affinity separations

摘要

A slowly rotating separation chamber with an oscillating axial magnetic field gradient created by an alternating current solenoid superimposed on a steady radial gradient in a horizontal chamber is used as part of a flow-through multiunit colloidal magnetic affinity separation device including magnets. The field-gradient induced microscale particle motion, as well as particle resuspension by chamber rotation, significantly enhances particle-target contact without generating damaging shear forces. Chamber rotation also minimizes sedimentation of non-neutrally buoyant magnetic particles. The alternating current solenoid are a series of coils arranged along the axial flow direction, a single chamber is utilized as a flow-through multistage separation device, leading to a major increase in volume and reduced “down” times as compared to batch equipment.