Method for inhibiting gene expression promoted by AP1 protein with RAR selective retinoids and method for treatment of diseases and conditions with such retinoids

摘要

Retinoid compounds which repress expression of the gene promoted by AP1 protein but which do not significantly activate expression of the genes having RA-responsive elements in their promoter region through RAR and RAR receptor subtypes, are used, with reduced side effects, for treating diseases and conditions which are responsive to therapy with retinoids.