Biphenyl Derivatives, a process for their preparation, their use for preparing a Drug, medicinal products based estoscompuestos,Pharmaceutical compositions containing them and Process for preparing such Pharmaceutical compositions.

摘要

Biphenyl derivatives of formula (1) wherein R1, R4 independently represent -C (= NH) -NH2 which may also be monosubstituted with -COA, -CO- [C (R6) 2] n-Ar, -COOA, - OH or with a conventional amino protecting group, NH-C (= NH) -NH2, -CO-N = C (NH2) 2, formulas (2) (3),R2, R3, R5 independently represent H, A, OR6, N (R6) 2, NO2, CN, Hal, NHCOA, NHCOAr, NHSO2A, NHSO2Ar, COOR3, CON (R6) 2, CONHAr, COOR6, COAr, S (O) nA, S (O) nAr, -O- [C (R6) 2] m-COOR6, - [C (R6) 2] p-COOR6, -O- [C (R6) 2] m-CON (R6) 2, [C (R6) 2] p-CON (R6) 2, -O - [(R6) 2] m-CONHAr, or - [C (R6) 2] p-CONHAr, X represents - [C (R6 ) 2] n -, - CR6 = CR6 -, - [C (R6) 2] nO-,-O- C (R6) 2 n- -COO--OOC -, - CONR6- or -NR6CO-,R6 representa HA o bencilo A representa alquilo de 1 a 20 tomos de carbono en el cual uno o dos gruposde CH2 pueden estar reemplazadospor tomos de 0 o S o por grupos de -CR6 3DCR6 y 2Fo 1 a 7 tomos de H pueden estar reemplazados por And the salts of these compounds 1. Procedures for preparing these compounds and their salts, i.e. (a) separating them from a functional derivative by treatment with a Soviet or hydrogenolysis agent, (b) converting one or more R1, R2, R3, R4 and / or R5 residues to one or more R1, R2, R3, R4 and / or R5 residues, And / or (c) converting a formula group or acid to its salts. It also describes a formula for a drug, a drug ingredient containing at least one formula, and a procedure for preparing these drug ingredients,A formula compound is an inhibitor of XA coagulation factor, which can be used for disease prevention and / or treatment; a formula compound is an anticoagulation factor.