Benzotiepina derived Compound, Pharmaceutical composition containing them, method for the prophylaxis or treatment of a condition hiperlipidemica,Use of this compound and processes for Preparation thereof

摘要

Benzotiepina responds to the Derivative of the formula (i) where: q is an integer from 1 to 4; n is an integer from 0 to 2; R1 and R2 are seleccionanindependientemente group consisting of H, alkyl,Alquenilo, alquinilo, haloalquilo, alkylaryl, arylalkyl, alkoxy, alkoxyalkyl esters, dialquilamino, Alquiltio (polialquil) aryl and alkyl, cycloalkyl, where the alquenilo alquinilo haloalquilo,,,,Alkylaryl, arylalkyl, alkoxy, dialquilamino, Alquiltio alkoxyalkyl esters, aryl, (polialquil)And is optionally substituted cycloalkyl with one or more substituents selected from the group formed by or9, nr9r10 r9r10rwa -, N +, r9r10a SR9, S + P + -, - S (o) r9r10r11a, R9, so2r9, so3r9, co2r9, NS,Halogen, Oxo, and conr9r10, where the alquenilo, alkyl, alkoxy, alquinilo, alkylaryl, alkoxyalkyl esters, aryl (polialquil), and optionally one or more carbons possess cycloalkyl substituted for or, NR9,N + r9r10a -, S, so, SO2, r9a + S + - P - phenylene or, where r9r10a, R9, R10, and RW are selected independently from the group consisting of H, alkyl, cycloalkyl, aryl alquenilo, Alquinilo acyl,,,Heterocycle, amonioalquilo, arylalkyl, carboxialquilo, carboxiheteroarilo, carboxiheterociclo, carboalcoxialquilo, carboxialquilamino, heteroarilalquilo,Heterociclilalquilo and alquilamonioalquilo; R1 and R2 together with C which are United, form C3 cycloalkyl - 10; R3 and R4 seseleccionan irrespective of the group consisting of H,Alquenilo, alquinilo alkyl, aryl, Heterocyclic, aciloxi, or9 nr9r10 SR9,,,, S (OR) so2r9 R9, and so3r9, R9 and R10 are as defined above; or R3 and R4 together form or nor11 =, =, = SNnr11r12 NR9 =, =, = cr11r12 R11 and R12 seleccionanindependientemente, where is the group consisting of H, alkyl, aryl, alquenilo, alquinilo, arylalkyl alquenilalquilo alquinilalquilo,,,Heterocycle, carboxialquilo, carboalcoxialquilo or cycloalkyl, cianoalquilo, or9 nr9r10 SR9, S (,, OR) so2r9, R9, so3r9, co2r9, CN, halogen, oxo and conr9r10,Where are Sedefinieron R9 and R10 as above, provided that both R3 and R4 are not Oh, NH2, sh, or R11 and R12 along with the nitrogen Atom or C that are United to form a ring,