A substance, in particular a ribozyme can inhibit the expression of Presenilin 2, a recombinant DNA Molecule encoding the ribozymeUnvector comprising the recombinant ribozyme cDNA corresponding to this, a host Cell comprising Said recombinant vector, C

摘要

Describes a substance capable of inhibiting the expression of Presenilin 2 in Neurodegenerative Diseases, including Alzheimer's disease.These substances are, in particular, specific RNA ribozymes capable of Segmenting the Presenilin 2.Preferably, these ribozymes ribozymes are defusion comprising a specific ribozyme Presenilin 2 and a Hammer Head ribozyme in autocatalytic.It also describes dnarecombinante molecules that encode dichasribozimas,A recombinant vector comprising the cDNA corresponding to these ribozymes and a host cell for the recombinant vector.It also describes Pharmaceutical compositions containing such Substance or ribozyme or recombinant DNA Molecule or dichovector and a pharmaceutically acceptable vehicle.It also describes the use of the substance or ribozyme or vectorrecombinante Said DNA Molecule or in the preparation of a Medicament for the treatment of Neurodegenerative Diseases.Finally, we describe a procedure for production of the ribozyme as referred to above,In which an automatic Synthesizer synthesizes a New DNA Molecule as such.In this way, substances are provided to reduce neuronal cell death due to apoptosis, which may be used to treat diseases including neurodegenerativeIn particular, Alzheimer's disease.Unlike the only symptomatic treatments available on State of the art.These substances allow a disease modifying therapy to address the pathology of it.