Monocyclic Compounds, Pharmaceutical compositions containing them and their use as taquiquinina NK2 Receptor Antagonists in the treatment of depatologias where release of Tachykinin

摘要

The monocyclic compounds in general formula (1), in which: x1, X2, X3, x4, whether equal or different, constitute a group from: - conr -.-NRCO -, - CH2-NR-,-Nr-ch2-r is h, c1-3 tar, benzene; F and m, whether equal or different, are the selected numbers between 0, 1 and 2; R1 and R2, whether marine or different, constitute a group - (CH2) r-ar, R equals 0, 1, 2, AR is an aromatic group, selected from benzene, naflina, thiophosphor, benzothion, pyridine, quinine, indola, furan, 1. Benzofuran, tiazol, benzotiazol, imidazol, benzoimidazol can be replaced by up to two substitutes selected from c1-3 tar, halogenated tar, c1-3 tar, aminobenzene c2-4-alkyl, halogen, O H, NH2, CN, n6r7, donder6 and R7. No matter whether these substitutes are the same or not, they are h or c1-3 tar;R3 is a group selected from the following groups: ((CH2) r-ar1, R equals to 0, 1, 2, AR1 is an aromatic group, selected from benzene, naflina, thiophosphor, benzothion, pyridine, quinoline, indol, furan, benzofuran, tiazor, benzothion, imidazole, benzopidan, The most two substitutes selected from c1-3 tar and halogen tar, c1-3 tar and aminobenzene, halogen, O H, NH2, CN, nr6r7, wherein R6 and R7, whether equal or different, are h or c1-3; R5 is h; R4 is a group selected from: - n8r9: R8 is h or alkyl 1-3; r9 is sulfur, Tetrahydropyridine tetrahydrophenyl etherIt may be monomer or carbon dioxide in the atom, which is replaced by c1-3 tar, c1-3 acid solution, Sulfanilamide and thiomethane in N atom; or a group of (CH2) g-r10, where G is 1, 2, 3 and R10, calculated between morfolino, Furano and CN; Or R8 and R9, together with the associated N atoms, constitute a pipe, which may be replaced by c1-3, c1-3 ACIO or sulfomethane in a kind of susnitrogene; n (R11) CO (CH2) h-r12 in which R11 is h or c1-3 hydrocarbon; h is 0, 1, 2, 3; R12 sesesessessessessessione is between: morfolino and pirrolidino may be replaced by hydroxy or hydroxyethyl, piperidina May be affected by a hydrogen oxide compound or