首页> 外国专利> Peptides that act as inhibitors of Integrin alfavbeta6, drugs containing these Peptides, Pharmaceutical compositions containing at least one of these Peptides,The use of these peptides in preparing a Medicine, recombinant DNA sequences that encode a FRA

Peptides that act as inhibitors of Integrin alfavbeta6, drugs containing these Peptides, Pharmaceutical compositions containing at least one of these Peptides,The use of these peptides in preparing a Medicine, recombinant DNA sequences that encode a FRA

机译:充当整合素alfavbeta6抑制剂的肽,包含这些肽的药物,包含至少一种这些肽的药物组合物,这些肽在制备药物中的用途,编码FRA的重组DNA序列

摘要

The formula peptide (1) w1-x1n Arg x2 ASP Leu X3 X4 Leu X5 X6 m-w2, wherein x1, X2, X3, x4, X5, X6 independently represent the remaining deaminora, in which, the selection of amino acids is independent of ala, ASN, ASP, Arg, CIS, Gln, Glu, fin, his LLE, Leu, Liu, LIS, mentlee, Ho Fen, pro, TR, Ser, Ser, TIR, O Val, in which the amino acids mentioned can also be derivatives, W1 stands for H or AC, W2 stands for Oh, or, NHR, NR2 NH2,R stands for 1 to 6 C and N and M atoms with independent numbers of 9 to 15. 1. A drug for inhibition, which can be used to control the characterization of V beta6 receptor and diseases caused by pathological functions, including thrombosis, myocardial infarction, coronary heart disease, aneurysm, osteoporosis and fibrosis, Inflammation, infection, psychosis,It also affects the healing process 1. Use of deformable peptide (1) as a drug for the treatment of the above diseases. Contains pharmaceutical ingredients containing at least anesthetics, as well as possible pre disinfectants and / or adjuvants and possibly other active substances. Nitrous oxide (adnrecom) contains a sequence that encodes a recipe peptide (1), a virus containing a capsule protein whose sequence is equivalent to or even a recipe peptide,A drug based on antiviral drugs was developed by using this virus. The drug was based on the expression and pathological function of alfav beta6 receptor.
机译:式(1)w1-x1n Arg x2 ASP Leu X3 X4 Leu X5 X6 m-w2,其中x1,X2,X3,x4,X5,X6独立地代表剩余的脱氨基,其中氨基酸的选择是独立的ala,ASN,ASP,Arg,CIS,Gln,Glu,fin,他的LLE,Leu,Liu,LIS,mentlee,Ho Fen,pro,TR,Ser,Ser,TIR,O Val的组成,其中提到的氨基酸也可以是衍生物,W1代表H或AC,W2代表Oh,或者,NHR,NR2 NH2,R代表1至6个C,N和M原子具有独立的9至15。1.抑制药物可以用于控制V beta6受体的表征以及由病理功能引起的疾病,包括血栓形成,心肌梗塞,冠心病,动脉瘤,骨质疏松症和纤维化,炎症,感染,精神病,还影响愈合过程1。可变形肽(1)作为用于治疗上述疾病的药物的用途。包含至少包含麻醉剂以及可能的预消毒剂和/或佐剂以及可能的其他活性物质的药物成分。一氧化二氮(adnrecom)包含一个编码配方肽(1)的序列,该序列是一种含有胶囊蛋白的病毒,该蛋白的序列等于或什至是一种配方肽。使用该病毒开发了一种基于抗病毒药物的药物。该药物基于alfav beta6受体的表达和病理功能。

著录项

  • 公开/公告号AR022395A1

    专利类型

  • 公开/公告日2002-09-04

    原文格式PDF

  • 申请/专利号AR1999P106525

  • 发明设计人

    申请日1999-12-17

  • 分类号C07K7/06;A61K38/08;C12N15/11;C12N7/01;C12N7/00;

  • 国家 AR

  • 入库时间 2022-08-22 00:46:28

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