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NITROBENZAMIDES USEFUL AS ANTIARITHMIC MEANS
NITROBENZAMIDES USEFUL AS ANTIARITHMIC MEANS
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机译:硝基苯甲酰胺类常用作抗麻醉药
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摘要
The invention relates to compounds with the formula or their salts or solvate, in which formula Ar means substituted or unsubstituted aryl, wherein the optional substituents are selected among C1-6 alkyl, hydroxy or C1-6 alkoxy; A means C1-4 n-alkylene group where each carbon atom is optionally substituted by one or two C1-6 alkyl groups; R1 means hydrogen or C1-6 alkyl; R2 is 4-nitrogroup; each R3 and R4 means hydrogen; X is -CO-NH-group and Z means CH2CH2CH2. The invention also relates to a method for the preparation of the said compounds, to pharmaceutical compound thereof, and to their use in medicine. 8 claims
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机译:本发明涉及具有下式的化合物或其盐或溶剂化物,其中式Ar表示取代或未取代的芳基,其中任选的取代基选自C 1-6烷基,羟基或C 1-6烷氧基;表示C 1-4正亚烷基,其中每个碳原子任选地被一个或两个C 1-6烷基取代; R 1表示氢或C 1-6烷基; R 2为4-硝基; R 3和R 4分别表示氢。 X为-CO-NH-基团,Z为CH 2 CH 2 CH 2。本发明还涉及所述化合物的制备方法,其药物化合物及其在医学中的用途。 8项
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