Nucleotide sequence of a Gene variant of the low density lipoprotein receptor LDL 5Associated with high Bone Density (HBM) encoded Protein; Variant; uses the variant test methods; identification of modulatory Molecules of bone density and uses in DisorderAssociated with the development of the bone.

摘要

This incvencion relates to methods and materials used to isolate and detect a high Bone Density Gene and a Gene of the native Types, and these mutants.The present Invention also relates to the High Bone Density Gene, The Gene type of the native and Mutant.The genes identified in the present Invention are implicated in bone Development and in the Signalling of focal adhesion.The Invention also provides Nucleic Acids, including Coding sequences, oligonucleotide primers and Probes inicidores, Proteins, cloning vectors, Expression Vectors,Guests processed methods Development, Pharmacological compositions, Methods of identifying molecules involved in bone Development.And Methods of Diagnosis and Treatment of diseases involved in the development of Bone.In Preferred settings, the present Invention is directed to methods for treating, Diagnosing and Preventing osteoporosis.