Derivative ciclobut - 3 - ene - 1.2 - dione and 3,4 - diamino substituted 1,2,5 thiadiazole - 1.1 - dione - 3.4 - diamino substituted and a Pharmaceutical composition useful for the treatment of AtherosclerosisUrinary incontinence, Type II Diabetes and obesity.

摘要

The present Invention provides compounds of formula I which have the following Structure: wherein R1, R2 and x are as defined earlier in this,Or a pharmaceutically acceptable Salt of sameWhich are useful for the Treatment or inhibition of Metabolic Disorders related to insulin resistance or hyperglycemia or Obesity (typicallyThe Glucose intolerance, gastrointestinal disorders, atherosclerosis, Neurogenic inflammation, glaucoma,Ocular hypertension and frequent urination; they are particularly useful in the Treatment or inhibition of Type II diabetes.