Metalloprotease inhibitors containing alquenilo Nile and they are effective in treating conditions CA - racterizadas by excessive activity of these Enzymes.

摘要

The invention refers to a compound whose structure is according to formula (I) EMI file = "00015564" U1 "id =" 1 "IMF = JPEG gt"; wherein: (a) x is selected from - oh and - nhoh; and (b) w is selected from - S -.- that is...-N (R33)-C (R33) 3DC (R33) --N 3DC (R33) -and -N = N -, (C) R1 is - (CR6R6´) / R34, (O) R2 is - (CR7R7´) m-R35, (E) R3 is - (CR8R8´) n-R9, (F ) R4 is - (CR10R10 ') zA' - (CR10 "R10" '') or -R11. (G) Each R5 and R5 'is independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroalkyl, heteroaryl, cycloalkyl, heterocycloalkyl, halogen, haloalkyl, hydroxy, and alkoxy; and k is from O to about 4; (H) A is selected from EMI FILE = "00015564_2" ID = "2" IMF = JPEG where each R12 and R12´ is independently selected from hydrogen, alkyl, alkenyl, alkynyl, haloalkyl , aryl, heteroalkyl, heteroaryl, heterocycloalkyl, cycloalkyl,(i) ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "00015564 U3" id = "3" IMF = JPEG (4)(a) E and j are independent from - (H) - (y); (b) l from - (s) -.- that is...-N (R38) --C (R38) 3DC (R38) -N 3DC (R38) -Y-n = n -, (c) w is about 0-4; (d) each R36 and R36 'is screened in the form of independent hydrogen, asphalt, bauxite, asphalt, arilo, ISO tar, ISO tar, ISO tar, cyclopentanediol, ISO cyclopentadiene, halogen, halogen, hydroxyl and alcoxi; (E) M is selected from the covalent bond, - 0 -.-SOx, -C (O) -,-C (0) NR39-- No. thirty-ninthY-nr39c (0); (f) t is - (cr40r40) and - R41, or an optical isomer, a symmetric isomer, or a corresponding isomer for calculating formula (I),It's either a pharmaceutically acceptable salt, or an amide, ester, or biological hydrochloride.