Antagonists of the il-8 receptor Feminist il-8

摘要

A compound of formula (I): EMI FILE = "00038195_1" ID = "1" IMF = JPEG where: R is OH, SH, NHSO2Rd; Rd is NR6R7, alkyl, aryl-C1-4alkyl, aryl- C2-4 alkenyl, heteroaryl, heteroaryl-C1-4alkyl, heteroaryl-C2-4alkenyl, heterocyclic radical, heterocyclyl-C1-4alkyl, where the aryl, hetearyl and heterocyclic rings may be optionally substituted; R6 and R7 are, independently , hydrogen, or a C1-4 alkyl group, or R6 and R7, together with the nitrogen to which they are attached, form a 5-7 membered ring, the ring of which may optionally contain an additional heteroatom which is selected from oxygen, nitrogen or sulfur,y cuyo anillo puede estar opcionalmente sustituido R1 se selecciona independientemente entre hidr geno hal geno nitro ciano C1-10 halosustituido alquilo C1-10 alquenilo C2-10 alcoxi C1-10 alcoxi C1-10 halosustituido azida (CR8R8) qS (O) tR4 hidroxi alquilo alkenyl C2-10-C (O) OR11, (CR8R8) qC (O) OR12, (CR8R8) qOC (O) R11, (CR8R8) qNR4C (O) R11, (CR8R8) qNHS (O) 2R17, (CR8R8) qS (O) 2NR4R5, or two residues R1 together can form O- (CH2) sO- or a 5- to 6-membered unsaturated ring; R2 is independently selected from C2-5 alkyl and C2-5 alkenyl, and all of these residues may be optionally substituted one to three times, independently, with halogen, nitro, halosubstituted C1-4alkyl, C1-4alkyl, amino, mono- or di-C1-4alkyl substituted amine, hydroxy, C1-4alkoxy, NR9C (O) Ra, S (O) mRa, C (O) NR6R7, C (O) OH, C (O) ORa, S (O) 2NR6R7, NHS (O) 2Ra, and may optionally contain, in addition to carbon independently 1 to 3 residues NR9, O, C (O),S. So, and SO2; R3 are independently selected from C1-10 tar, C1-10 halogen tar, alquenilo C2-10 and alcoxi C1-10.