Antagonists of the il-8 receptors gonistas of il-8

摘要

Compound administered in effective amount to a Mammal for the treatment of a disease mediated by chemokine, selected from the group consisting of malaria, restinosis,Angiogenesis, atherosclerosis, osteoporosis, gingivitis, unwanted release of Haematopoietic stem cells and diseases caused by Respiratory virus, herpes virus, and hepatitis virus,The chemokine that binds to a receptor or beta il-8, The Compound of formula (i) EMI file = "00044292 _ 1" id = "1" = : JPEG MFIs where z is or11, cyano, C (or c) nr15r16, R11 R18 (,, OR)Or s (OR) is 2r17; nitrogenUnder the condition that only one or two of the TRACES are the remaining Carbon and Nitrogen are replaced with Hydrogen or R1, R is any other functional or ionizable Hydrogen and has aN PKA of 10 or less; r1 is selected independentlyBetween Hydrogen, halogen, Nitro, cyano - 10 halosustituido C1; rent; rent alquenilo C1 - C2 - 10; 10; alkoxy C1 C1 - alkoxy - 10; 10 halosustituido; AZIDE; (cr8r8) QS (TR4); hydroxy c1-4 alkyl, HydroxyAryl alkyl; aryl; c1-4, ariloxi; aryl heteroaryl alquiloxi c1-4, heteroarilalquilo; radical; heterocycle; heterociclil c1-4 alkyl; heteroaryl - alquiloxi C1 - C2 - 4; alquenilo aryl heteroaryl - 10;Alquenilo C2 - 10; heterociclil - alquenilo C2 - 10; (cr8r8) qnr4r5; alquenil C2 - 10 - C (o) nr4r5 (cr8r8); (o) nr4r5 QC QC (cr8r8); (o) nr4r10; S (or S) 3h; (o) (cr8r8 QC (3R8); or R11; alquenil C2 - 10 - C (o) R11; alquenil C2 - 10 -(c) or11; (cr8r8) QC (or or12 (QOC); cr8r8 (R11); (o) cr8r8) qnr4c (R11); (cr8r8) QNHS (or 2r19 (QS) or cr8r8) or two (or 2nr4r5); r1 remains together can form or - (CH2) - or a saturated or unsaturated Ring 5 6Members; Q is 0 or an integer number that has a value of 1 to 10; t is 0 or an integer number that has a value of 1 or 2; s is an integer that has a value of 1 to 3 V is 0;Or a whole number that has a value of 1 to 4; R4 and R5 are independently Hydrogen, optionally substituted c1-4 alkyl, optionally substituted aryl,(optionally substituted aryl alkyl C1) - 4 - (heteroaryl heteroaryl, optionally substituted, optionally substituted alkyl) - C1 - 4, Heterocyclic radical or heterociclil c1-4 alkyl,Or R4 and R5 with nitrogen are United to form a Ring of 5 to 7 members that can contain an optional additional heteroatom selected from o / N / s;...