Transdermal therapeutic system with low thickness of administration area and great flexibility and method of preparation thereof

摘要

PCT No. PCT/EP97/01252 Sec. 371 Date Apr. 26, 1999 Sec. 102(e) Date Apr. 26, 1999 PCT Filed Mar. 12, 1997 PCT Pub. No. WO97/35564 PCT Pub. Date Oct. 2, 1997A transdermal therapeutic system for the release of active substances to a substrate is characterized by the structure of the system comprising a substrate (1) provided with a separating layer (2), a film layer (3) comprising the active substance, and a protective layer (4) provided with a nonstick finish, the separating layer (2) consisting of a material whose bond to the film layer (3) may be abolished. By means of printing methods, such systems having small application thickness and high flexibility can be manufactured, it being possible to provide a substrate that has been rendered adhesive as an alternative to the substrate/separating layer-complex. A printing method limiting the active substance-containing region to the application site reduces disposal problems.