application of benzothiophener in the manufacture of medicaments for the treatment of acute respiratory distress syndrome

摘要

Benzothiophenes of formula (I) and their salts are new: X1, Y1 = O or S; R1, R2 = H or OR4; R4 = H, 1-6C alkyl or phenyl opt. mono- or disubstd. by halo, CF3, 1-6C alkyl, OH, 1-6C alkoxy, 1-6C alkylthio or COOR10; or R4 is opt. substd phenyl and is attached to the benzothiophene or benzofuran ring system through a 1-4C alkylene; R10 = H, 1-6C alkyl, NO2, NH2, mono-or di(1-6C alkyl)amino; R3 = R4 except H; (is when R11R2 = OH or alkoxy, then R3 cannot be alkyl or aralkyl, and both R1 and R2cannot be H. Also claimed is use of a pharmaceutical compsn. cont. (II), for treating acute respiratory distress, synchronie in humans. Y2, Y2 = O or S; R6, R7 = H, halo or OR8; R8 = R4 except 1-6C alkyl; if R1 and R2 cannot both be H; R5 = R8.