New 15-spinal ketoasalides, method of manufacture and pharmaceutical composition containing these for bacterial infections

摘要

The present invention relates to the new 15-membered ketoazalides from the class of 6-O-methyl-8a-aza-8a-homo-and 6-O-methyl-9a-aza-9a-homoerythromycin A with the general formula (I) wherein A represents NH group and B at the same time represents C=O group, or A represents C=O group and B at the same time represents NH group, R1 represents OH group, L-cladinosyl group of the formula (II) or together with R2 represents ketone, R2 represents hydrogen or together with R1 represents ketone, R3 represents hydrogen or C1-C4alkanoyl group, to intermediates and a process for their preparation, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to the process for the preparation of pharmaceutical compositions, as well as to the use of pharmaceutical compositions for treating bacterial infections.