NEW 6-AMINO- OR 6-HYDRAZINO-SULPHONYL-3-QUINOLINYL-PHOSPHONIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The present invention relates to compounds of formula I, their enantiomers and diastereomers, and addition salts thereof with pharmaceutically acceptable acids or bases, wherein R 1 is halogen or trifluoromethyl, R 2 is hydrogen or alkyl or cycloalkyl, R 3 is alkyl, cycloalkyl, aryl, arylalkyl, alkoxy, aryloxy, arylalkoxy, hydroxy, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkylcarbonyl, arylcarbonyl or arylalkylcarbonyl or NHR6 (wherein R6 is hydrogen or alkyl, cycloalkyl, aryl, alkylcarbonyl); arylcarbonyl, arylalkyl or arylalkylcarbonyl) or R 2 and R 3 taken together with the nitrogen atom to which they are attached form a 5 or 6 membered ring in which one carbon atom is replaced by an oxygen, nitrogen or sulfur atom or an SO or SO 2 group or an NRa Is hydrogen or alkyl, cycloalkyl, aryl or arylalkyl), R4 and R5 may be or different and are selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, and arylalkyl, or a group of the general formula (wherein R 7 and R 8 may be the same or different and are hydrogen or alkyl, cycloalkyl or aryl). The invention also relates to a process for the preparation of the above compounds of formula (I) and to pharmaceutical compositions containing such compounds as active ingredients. The above compounds are contraindicated in neurological and psychological disorders. HE