NOVEL 1,2,5-TRISUBSTITUTED 1,2-DIHYDRO-INDAZOL-3-ONES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The present invention provides novel 1,2,5-substituted 1,2-dihydroindazol-3-one derivatives of formula (I) wherein X is -SO2-, -SO-, - (CH2) p-, - (CH2) pO-, - (CH2) p- (C = O) -, - (CH2) p- (C = O) -NH-, - (CH2) p-CHOH-, -CHOH- (CH2) p -, - (CH 2) p -CH = CH-, -CH = CH- (CH 2) p - where p is 1, 2, 3 or 4, Y is - (C = O) -, - (C = O). ) -NH-, - (C = O) -NH- (CH 2) p -, - (C = O) - (CH 2) p -, - (CH 2) p O -, - (CH 2) p - (C = O). ) -, - (CH 2) p - (C = O) -NH-, - (CH 2) p - (C = O) -NH- (CH 2) p -, - (CH 2) p -CHOH-, -CHOH - (CH2) p-, - (CH2) p-CH = CH-, -CH = CH- (CH2) p-, wherein p is 1, 2, 3 or 4, Z is -O-, -O- ( CH 2) p - (p = 1, 2, 3 or 4) or -NH-, -NH- (C = O) -, -NH- (C = O) -NH-, -NH- (C = O) -O-, -NH-CH 2 - (C = O) - or -NH- (C = O) -CH 2, R 1, R 2 and R 3 are the same or different and can be selected from the group consisting of 5-14 ring members, mono-, bi- or tricyclic, saturated or singly or multiply unsaturated carbocycle, preferably phenyl, naphthyl, anthranil, fluorenyl, mono-, bi- or tricyclic, saturated, 5-15 ring members or a single or polyunsaturated heterocyclic group containing from 1 to 6 heteroatoms, preferably N, O and / or S, preferably thienyl, pyridinyl, isoxazolyl, benzomidazolyl, benz [1,3] dioxolyl, pyrimidinyl; , quinolyl, quinazolinyl, morpholinyl, pyrrolidinyl, pyrrolyl, phenyl [1,2,4] oxadiazolyl or phenylthiazolyl, and acarbocyclic and heterocyclic groups may be singly or multiply substituted, respectively, for their preparation and their use as therapeutic agents. The compounds have anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulatory properties. SHE