SPIRO PIPERIDINE-4,1'-PYRROLO3,4-CPYRROLE DERIVATIVES AS AGONIST AND/OR ANTAGONIST OF THE ORPHANIN FQ(OFQ)RECEPTOR, PREPARATION AND USE THEREOF

摘要

The present invention relates to compounds of the general formula CHEM wherein the substituents are described in the application and to pharmaceutically acceptable acid addition salts thereof. The compound of the invention are useful in the treatment of diseases related to the orphanin FQ (OFQ) receptor, which include psychiatric, neurological and physiological disorders, such as anxiety and stress disorders, depression, trauma, memory loss due to Alzheimer's disease or other dementias, deficits in cognition and leaning, epilepsy and convulsions, acute and/or chronic pain conditions, and symptoms of addictive drug withdrawal, control of water balance, Na+ excretion, arterial blood pressure disorders and metabolic disorders such as obesity.