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SYNTHETIC MEMBRANE VESICLES WITH CONTROLLED RELEASE OF ENCAPSULATED BIOLOGICALLY ACTIVE SUBSTANCES, PROCESS FOR THEIR PREPARATION AND A TARGETED DELIVERY SYSTEM COMPRISING THEM
SYNTHETIC MEMBRANE VESICLES WITH CONTROLLED RELEASE OF ENCAPSULATED BIOLOGICALLY ACTIVE SUBSTANCES, PROCESS FOR THEIR PREPARATION AND A TARGETED DELIVERY SYSTEM COMPRISING THEM
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机译:封装的生物活性物质具有受控释放的合成膜囊泡,其制备过程和包括它们的靶向递送系统
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摘要
A multivesicular liposome composition containing at least one acid other than a hydrohalic acid and at least one biologically active substance, the vesicles having defined size distribution, adjustable average size, internal chamber size and number, provides a controlled release rate of the biologically active substance from the composition. A process for making the composition features addition of a non-hydrohalic acid effective to sustain and control the rate of release of an encapsulated biologically active substance from the vesicles at therapeutic levels in vivo.
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