12H-DIBENZO d,g 1,3 DIOXOCINE SUBSTITUTED N-HETEROCYCLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Anti-diabetes mellitus compounds of the formula wherein R1 and R2 independently are hydrogen, halogen, trifluoromethyl, hydroxy, C1-6-alkyl or C1-6-alkoxy; and R3 is hydrogen or C1-3 alkyl; and A is C1-3-alkylene; and Y isOCH-CH2-, LC=CH-, LCH-O-, LC=N-, LN-CH2-, wherein only the underscored atom participates in the ring system; and Z is selected from 3640 כ" ח בשבט התשס" ב - February 10, 2002 wherein n is 1 or 2; and R11 is hydrogen or C1-6-alkyl; and R12 is hydrogen, C1-6-alkyl, C1-6-alkoxy or phenyl optionally substituted with halogen, trifluoromethyl, hydroxy, C1-6-alkyl or C1-6-alkoxy; and R13 is hydrogen, halogen, trifluoromethyl, hydroxy, C1-6-alkyl or C1-6-alkoxy; and R14 is -(CH2)m-OH or -(CH2)tCOR15 wherein m is 0, 1, 2, 3, 4, 5 or 6 and t is 0 or 1 and wherein R15 is -OH, NH2, -NHOH or C1-6-alkoxy; and R16 is C1-6-alkyl or -B-COR15, wherein B is C1-6-alkylene, C2-6-alkenylene or C2-6-alkynylene and R15 is the same as above; and - - - is optionally a single bond or a double bond; or a pharmaceutically acceptable salt thereof, with the proviso that if R1 and R2 independently are hydrogen, halogen or trifluoromethyl and Y is LN-CH2- then R16 cannot be C1-4-alkyl and further that the compound 2-[4-[3-(12H- dibenzo [d,g] [1,3,6] dioxazocin-12-yl)-1- propyl] -piperazin-1-yl]- ethanol is not included.