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A process for preparation of sterile cisplatin oil-in-water emulsion with reduced toxicity suitable for parenteral administration
A process for preparation of sterile cisplatin oil-in-water emulsion with reduced toxicity suitable for parenteral administration
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机译:一种适于胃肠外给药的毒性降低的无菌顺铂水包油乳剂的制备方法
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摘要
A sterile pharmaceutical cisplatin composition as an oil-in-water emulsion having low toxicity for parenteral administration comprising:a) an oily phase selected from the group consisting of: vegetable oils, esters of medium or long chain fatty acids, and fractionated or modified oils;b) cisplatin incorporated in the oily phase;c) an emulsifier selected from the group consisting of: natural phosphatides; modified phosphatides, and synthetic non-ionic surfactants;d) a tonicity modifying agent selected from the group of compounds consisting of: glycerin, mannitol, and dextrose;e) a chelating agent selected from the group of compounds consisting of: edetates, and desferrioxamine mesylate; andf) water.
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