Method for judging the possibility of the onset of sheep leukemia using the amino acid sequence 70 and 71 of the beta domain of the MHC class II DR beta chain

摘要

A convenient method for judging the possibility of the onset of leukaemia against bovine leukaemia virus (BLV) in sheep individuals by using genetic engineering techniques. According to this method, sheep individuals carrying an amino acid sequence Ser-Arg or Gln-Thr specified by the amino acid nos. 70 and 71 in the beta 1 domain of the sheep MHC Class II DR beta chain are regarded as being at the risk of the onset of leukaemia, while those carrying an amino acid sequence Arg-Lys as the same are regarded as being resistant to the onset of the disease.