Angiogenesis inhibitory composition comprising an inhibitory compound and antiinflammatory drug

摘要

A group of compounds that effectively inhibit angiogenesis is described. More specifically, the compounds comprise thalidomide or thalidomide precursors, analogues, metabolites and hydrolysis products, and antiinflammatory drugs, such as NSAIDs. The NSAIDs are selected from group consisting of aspirin, acetominophen, ibuprofen, esculetin, phenidone, quercetin, ketoprofen, nordihydroguiaretic acid (NDGA), sulindac, sulindac sulfone, sulindac sulfide, indomethacin, NS-398 (a cyclooxygenase-2 inhibitor), cyclooxygenase- 1 inhibitors, methylheptyl imidazole, furegrelate sodium, SKF525AHCL, thromboxane inhibitors, toradol, ecasa, salsalate, diflunisal, mefenamic acid, naproxen, naproxen sodium, floctafenine, meclofenamate, phenylbutazone, oxyphenbutazone, diclofenac, etodolac, fenoprofen, flufenamic acid, flurbiprofen, pirprofen, tolmetin, apazone, fenbufen, nabumetone, oxaprozin, piroxicam, salicylate, and tenoxicam. Importantly, these compounds can be administered orally.