An orally administrable pharmaceutical composition comprising an inner core and two outer layers, which render it substantially free of unpleasant tastes

摘要

A pharmaceutical composition that is substantially free of unpleasant tastes and orally administrable is described. It comprises: (a) an active medicament, (b) an inner coating layer comprising an oil substance having a melting point in the range 50-100 oC, (c) an outer coating layer comprising a polymeric substance. The active medicament and the inner coating layer form the inner core, the active medicament is about 5-65% by weight of the total inner care, the oil substance is about 35-95% by weight of the total inner core and the polymeric substance is about 4-90% by weight of the total composition. The oil substance can be chosen from soybean oil, avocado oil, squalene oil, sesame oil, olive oil, canola oil, corn oil, rapeseed oil, safflower oil, sunflower oil, fish oils, flavoured oils, water insoluble vitamins and a polyethylene glycol polymer having a melting point at least above 500 oC or mixtures thereof.