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Modified amino acid sequence of receptor provide other ligands to bind and stabilise the active state conformation of the receptor
Modified amino acid sequence of receptor provide other ligands to bind and stabilise the active state conformation of the receptor
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机译:受体的修饰氨基酸序列提供了其他配体,以结合并稳定受体的活性状态构象
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摘要
Disclosed herein are techniques for directly identifying candidate compounds as agonists, partial agonists and/or, most preferably, inverse agonists, to endogenous, constitutively activated orphan G protein-coupled receptors. Such directly identified compounds can be utilized, most preferably, in pharmaceutical compositions.
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